Principles of Medical Biochemistry (4th Edition) Edit edition

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The 2,3-bisphosphoglycerate regulates the oxygen binding to hemoglobin. The BPG concentration is increased in lung diseases, adaptation to high altitude and severe anaemia. It enhances the uploading of oxygen in the tissues where the oxygen partial pressure is perpendicular to oxygen-binding curve.

The BPG has negative allosteric effector in the case of oxygen binding to hemoglobin because it lowers the oxygen affinity. But a positive allosteric effector will increase the oxygen affinity.

The 2,3-bisphosphoglycerate which is present in red blood cells, but it does not bind to any functional groups such as sulfhydryl groups, alcoholic hydroxyl groups, hydrocarbons groups which is absent in hemoglobin, carboxyl group of hemoglobin at pH 7.0.

Hence, options (A), (B), (C), and (E) are incorrect.

The BPG binds noncovalently to hemoglobin. It binds covalently with the amino terminus of β-chains with side chains of Lys EF6 and His H21 in the β-chains in the hemoglobin.

Therefore, option is the correct answer.